Lasiopetalum oppositifolium is a species of flowering plant in the family Malvaceae and is endemic to the south-west of Western Australia.

It is an open, erect shrub with rusty-hairy young stems, linear, narrowly elliptic or narrowly egg-shaped leaves and white, pink and dark red flowers.

[2][3] Lasiopetalum oppositifolium was first formally described in 1860 by Ferdinand von Mueller in Fragmenta Phytographiae Australiae from specimens collected near the Murchison River by Augustus Oldfield.

[6] This lasiopetalum grows on cliffs, gorge slopes and breakaways in shrubland or scrub in a few places near Kalbarri in the Geraldton Sandplains biogeographic region of south-western Western Australia.

[2][3] Lasiopetalum oppositifolium is listed as "Priority Three" by the Government of Western Australia Department of Biodiversity, Conservation and Attractions,[2] meaning that it is poorly known and known from only a few locations but is not under imminent threat.