They have been living in the eastern Mediterranean coast of Lebanon and Syria since the middle Byzantine or the Ottoman era and in Constantinople (Istanbul), Smyrna (İzmir) and other parts of Anatolia (such as the port towns of Amasra, Sinop, Trabzon, Enez, Çanakkale, Foça, Çeşme, Bodrum, Alanya, Mersin, Iskenderun, etc., where the colonies of Genoese and Venetian merchants existed) in present-day Turkey.

[4] The name Italo-Levantine is specifically applied to people of Italian (especially Venetian or Genoese) origin, but even with some French or other Euro-Mediterranean roots, who have lived in Istanbul, İzmir and other parts of Anatolia in Turkey.

Some of the Italian Levantines may have ancestral origins also in the eastern Mediterranean coast (the Levant, particularly in present-day Lebanon and Israel) dating back to the period of the Crusades and the Byzantine Empire.

The majority of the Levantines in modern Turkey are the descendants of traders/colonists from the Italian maritime republics of the Mediterranean (especially Genoa and Venice) and France, who obtained special rights and privileges called the Capitulations from the Ottoman sultans in the 16th century.

[9] Famous people of the present-day Levantine community in Turkey include Maria Rita Epik, Franco-Levantine Caroline Giraud Koç and Italo-Levantine Giovanni Scognamillo.