It is owned by the Ferrovie dello Stato, the national rail company of Italy, and is an important train station of its region.

It is the most distant station from the city centre of an Italian seat of province: due to this, 9 km, local and regional authorities have presented several projects to build a rail, or a light rail, from it to an eventual "Latina Città" (i.e. Latina City) station.

In the early years of service, when the city of Latina didn't exist, it was a simple train stop serving some little villages close to the swamps composing the environment of the Pontine Marshes.

During this period some diesel multiple unit (DMU) trains were inaugurated in a regional Rome to Littoria service, colloquially named Littorine (plural) and Littorina (singular) after the city.

Located onto one of the principal Italian rail lines, the Rome-Latina-Formia-Naples, it is served for long-distance transport by several InterCity and Express trains to Rome, Turin, Milan, Naples, Venice, Palermo, Syracuse, Reggio Calabria and Bolzano, linking it also with Genoa, Bologna, Florence, Pisa, Verona, Catania, Messina and other cities.