He originally married Laura Biassa and had a son and a daughter; Felice Zacchia (mother of Cardinal Paolo Emilio Rondinini).
However, after his wife died, he left Vezzano and went to Rome to aid his brother, Cardinal Paolo Emilio Zacchia.
][5] When Urban travelled to Castel Gandolfo to rest, the members of the Spanish faction met in secret and discussed ways to progress their plan.
To put an end to the conspiracy, the pope decreed that all cardinal-bishops should leave Rome and return to their own churches.
[4] As it was, Zacchia died the following year, in 1637, and was buried in the chapel of Saint Domenico at the Church of Santa Maria sopra Minerva in Rome.