After the graduation with a Bachelor's degree in Business Economics, she worked for a short period in a tax assistance center.

After participating in the drafting of the so-called "government contract" between Five Star Movement and League, on 12 June she was appointed Undersecretary at the Ministry of Economy in the Conte Government.

[2] On 21 March 2019 she was promoted, together with Massimo Garavaglia (Lega Nord), Deputy Minister of Economy.

On 28 June 2021 the tribunal of Turin has convicted Laura Castelli for aggravated defamation.

The proceeding concerned a post on Facebook in which she edited a photo to make believe a flirt between Piero Fassino and a PD candidate for the 2016 administrative elections, Lidia Roscaneanu.