On December 12, 1992, President-elect Bill Clinton announced his intention to nominate Tyson as Chairman of the President's Council of Economic Advisers.

During her time with the Clinton administration, Tyson was a spokesperson in favour of GATT, arguing with Sir James Goldsmith on Charlie Rose that American jobs would be increased by the trade agreement.

After leaving politics, Tyson returned to UC Berkeley, becoming Dean of the Haas School of Business from 1998 to 2001.

Tyson has published a number of books and articles on industrial competitiveness, trade, and the economies of Central Europe and their transitions to market systems.

[9] The center is focused on finding solutions to address the crisis of extreme poverty and disease in the developing world.

[10] Tyson joined Berkeley Research Group, LLC, an expert services advisory firm co-founded by David Teece, as a special advisor in 2010.