After graduation, Little served as a law clerk for United States Court of Appeals for the Third Circuit Judge James Hunter III and then clerked for Supreme Court of the United States Chief Justice William Rehnquist.
Little later joined the law firm of Dechert Price & Rhoades and worked in general commercial litigation.
[2] Little has served as an appellate advocate and expert consultant on matters related to the conflict of laws, federal jurisdiction, and the U.S. Constitution.
She was appointed by the U.S. Court of Appeals for the Third Circuit to argue and brief the case of Trinsey v. Pennsylvania, which challenged senatorial succession processes under the U.S. Constitution's 17th Amendment.
Her book, "Guilty Pleasures: Comedy and Law in America," was published by Oxford University Press in 2018.