She first traveled to the Dakota Territory in June 1885, filing a pre-emption claim on 160 acres of land near New Rockford.

In 1889, she was elected superintendent of schools for Foster County, North Dakota, winning reelection the next year.

That year the Democratic Party endorsed her to run for the position of North Dakota Superintendent of Public Instruction.

Upon taking office in January, Eisenhuth's first action was to appoint a deputy, but her choice, W. R. Bierly, was turned down by governor Eli Shortridge.

[7][2] Her more ambitious goal, to build schools and improve others, was defeated by the Panic of 1893, which caused much trouble for the state economy.

[1][8] Other women, however, soon followed her example in other western states; Antoinette Peavey was elected in Colorado the same year that Eisenhuth lost her post, and Estelle Reel won in Wyoming in 1896.

They lost the newspaper which he had founded in Carrington, as well as the drugstore in that town and their home and possessions in Bismarck, due to unpaid county taxes.