MacFarlane also performs solo and has been in other bands, including as an early drummer and singer with United States rock group, Sleater-Kinney (1994–96).

[5] She performed in other local bands, including Halcyon Days on drums[5] and Louder than God, which had an extensive line-up of ten members, co-founded by Iain McIntyre.

"[4] In 1992, MacFarlane formed Sea Haggs (later renamed Keckle)[7] on guitar, viola, percussion and vocals, with McIntyre and Potts.

Woozy was a self-published fanzine, with a DIY philosophy, that promoted local Melbourne and Australian bands, as well as international underground acts and grassroots politics.

[8][9] MacFarlane began playing drums and vocals in 1994 with visiting United States rock group, Sleater-Kinney, and in 1995 she went to Olympia and Seattle to tour and record with the band.

[11] In 1996, MacFarlane returned to Melbourne and founded an indie rock band, ninetynine, initially as a solo project, playing all the instruments on the debut album, 99 (October 1996).

[12][14] MacFarlane founded her own record label, Patsy,[12][13] which issued ninetynine material, as well as that by the bands Sea Scouts, Fiona Beverage, Boo Who, Baseball, Trixies Undersea Adventure, and Vivian Girls.

[15] She has worked with other artists, including Lee Memorial (alongside Karl Smith of Sodastream),[16] Bombazine Black, The Wonder,[17] Winterborn, Tarantula,[14] New Buffalo,[18] Trixies Undersea Adventure, Boo Who, Popemobile,[19] Dragster, Scared of Horses, Cold Cold Hearts, Madigan, Disaster Plan, Clag, and Low Talk.