Laurel Run is a borough that is located in Luzerne County, Pennsylvania, United States.

The borough is home to one of the oldest continuing motorsport events in Pennsylvania.

Since 1906, the annual Giants Despair Hillclimb has challenged motorists to race uphill on a one-mile stretch of East Northampton Street.

[5] Approximately 166 homes, two grocery stores, a church, a school, and a lumberyard were razed and relocated through a program administered by the Appalachian Regional Commission.

[6] According to the United States Census Bureau, the borough has a total area of 5.2 square miles (13.4 km2), all land.

Laurel Run, a tributary of Mill Creek, flows through much of the borough.