She overcame a traumatic brain injury from cycling to complete graduate school studying epidemiology and win races as a professional cyclist.

[7] On May 31, 2020, De Crescenzo set the women's everesting world record,[8] ascending Hogpen Gap in Blairsville, Georgia 24 times in nine hours and fifty-seven minutes.

During her first professional racing season in 2016, she suffered a traumatic brain injury (TBI) following a bike crash, after which she was placed in a medically induced coma for six days.

[4] De Crescenzo had a lengthy rehabilitation period in Colorado, after which she could relearn basic tasks and return to bicycle racing and graduate school.

[13] Following her recovery, De Crescenzo has gone on to finish graduate school, complete a fellowship at the Centers for Disease Control, and win more bike races.