Jauregui began experimenting with different sounds and exploring solo songwriting, collaborating on songs with Marian Hill, Steve Aoki and Halsey.

[11][12][13] Throughout her school years, Jauregui expressed herself through the arts, while she enjoyed "constantly creating", singing, writing, dancing, choreographing, playing piano and painting.

[19][20] After being eliminated as a solo artist in the competition, Jauregui was brought back and put into a group alongside Ally Brooke, Normani, Dinah Jane, and Camila Cabello, which would later become Fifth Harmony.

"Work From Home", the album's lead single, peaked at number four on the Billboard Hot 100, and reached the top 10 in several international charts.

[24] In March 2018, the group announced their decision to take an indefinite hiatus to grow as individual artists and pursue solo ambitions.

Jauregui said that being able to "form a genuine connection" with the duo and write for the song was an "honor", while it gave "a snippet of my vibe for the first time in collaboration with them".

[27] Jeremy Lloyd of Marian Hill said that Jauregui told them she had written her verse about five minutes before she was going to record it, and she "nailed the rhyme scheme and did so probably quicker and more deftly than we could have done".

[30] In May 2017, Jauregui was voted by the public as "Celebrity of the Year" at the British LGBT Awards in recognition of promoting equality for LGBTQ.

[31] Jauregui featured on Halsey's song "Strangers",[32] which Billboard noted as a "long-overdue bisexual milestone in mainstream music.

[41] In June 2018, Jauregui was the opening act for Halsey's Latin American leg of her Hopeless Fountain Kingdom World Tour.

Jauregui released her debut solo single "Expectations" with its accompanying music video on October 24, 2018, under Columbia Records.

I'm also very intricately involved in every aspect of bringing each song to life – the video ideas, developing the concepts, the whole editing process.

[55] In early December 2019, Jauregui featured alongside Drew Love on Clear Eyes' (Jeremy Lloyd from Marian Hill) debut solo song, "Let Me Know".

[57] In February 2020, she collaborated with Puerto Rican producer Tainy on his Latin urban song "Nada" featuring Spanish artist C.

[64][65] In March 2020, Jauregui participated in Billboard's Live At-Home Concert to raise funds for coronavirus disease relief.

[66][67] She joined Global Citizen and the World Health Organization's Together at Home campaign series, for which she performed and spoke to raise awareness and funds for the coronavirus disease pandemic.

[70] In April 2021, Jauregui partnered with Ad Council's Sound It Out campaign, which encourages students and their caregivers to have honest conversations about mental health.

1 from female-led entertainment company Femme It Forward, which focuses on celebrating and empowering women and bringing more inclusivity in the music industry.

[74] The following month, Jauregui announced on her social networks that she is an ambassador for Rihanna's Savage X Fenty lingerie brand.

On September 15, 2021, Jauregui announced her debut solo project, Prelude, and a livestream performance via Moment House scheduled for October 14 and 15.

[82] In September, the song "Piña" debuted on digital platforms as a partnership between Jauregui and rapper Snow Tha Product.

On Friday (September 30), for logistical reasons, Lauren informed through her social networks that the shows in South America had been postponed to March 2023, in addition to adding Mexico, Colombia, Peru and the Dominican Republic to the list.

[90] Jauregui released the single "Burning", described as "an ode to my queerness and the unapologetic nature with which I embrace it regardless of my Catholic upbringing", on February 7, 2024 via EVEN.

[95] Some of the artists who have influenced her include Lana Del Rey,[96] John Mayer,[97] Lauryn Hill,[98][99] Paramore,[100] Alicia Keys,[100][101] Janelle Monáe,[102] Shakira,[103] Christina Aguilera,[100] Amy Winehouse,[104] and Frank Ocean.

[120] She has written several open letters since the 2016 United States presidential election, criticizing Donald Trump and his policies, including the "Muslim ban", calling it "disrespectful to humanity".