He holds the Marcel and Rolande Gosselin Research Chair in Cognitive Neuroscience of Autism at the University of Montreal since 2008, and is a fellow of the Canadian Academy of Health Sciences since 2019.

He is married to Quebec researcher Sylvie Belleville[2] and is the father of three children, including singer and songwriter Pierre Mottron.

His early work is part of the general neuropsychology of pervasive developmental disorders and focuses on visual and auditory perception in savant and non-savant autism, studied through cognitive tasks and brain imaging.

He is also interested in re-examining the role of intellectual disability, identifiable mutations and epilepsy in primary and syndromic autism, and the inclusion of autistic researchers in science.

More recently, he and his collaborators are trying to re-construct de novo "prototypical" phenotype of this condition, in order to reason its uncontrolled increasing reported prevalence.