She explored personal identity transformed through a synthesis of ancient mythological references, industrial tools, taxidermy, botanical illustrations and biological organisms (bioluminescent bacteria, pigs bladders, etc...).

Her eclectic use of materials explored combinations of the organic and synthetic: Kheper beetle, gold leaf, sheep manure, peat moss, overhead projectors, water, IV bags, glass, watercolours on enlarged EEG printouts.

"’[8] From the early 2000s onward, Walker’s output as an artist and career profile diminished after she was struck by Chronic Fatigue Immune Dysfunction Syndrome (CFIDS).

[9] While chronically ill, from 2005-2008, Walker completed a set of four large-scale drawings entitled Prometheus Rebound which were exhibited at Susan Hobbs Gallery in Toronto after her death in 2011.

The catalog for that show states: "Walker’s work held a high degree of fabrication, and was deliberately made from materials carrying weighty symbolic charges that echoed her deep interest in the natural sciences, ancient mythology, and environmental concerns.