[1] Her father, Lionel F. Jaffe, was a senior scientist at the Marine Biological Laboratory in the Woods Hole Oceanographic Institution.
[4] After graduating, Jaffe worked as a postdoctoral researcher at Woods Hole Oceanographic Institution with Lewis Tilney and at the University of California, San Diego with Meredith Gould.
The activity of these proteins result in the production of cyclic adenosine monophosphate (cAMP), which keeps the cell cycles arrested.
The signalling system within the granulosa cell switches in response to the luteinizing hormone, which Jaffe has shown lowers the cGMP.
This decrease in cGMP can be monitored using confocal microscopy of mice follicles that express the Fluorescence Resonance Energy Transfer (FRET) sensor cGi500.