Lawrence Clarke (June 26, 1832 – October 5, 1890, Prince Albert, Northwest Territories) was the Chief Factor of the Saskatchewan District of the Hudson's Bay Company.

Clarke moved to what is today Prince Albert, Saskatchewan in the early 1880s and was a prominent local citizen with connections in the Conservative Party of Canada.

He questioned Gabriel Dumont for fining a group of Métis who had begun to hunt bison before the official hunt of the St. Laurent community in the spring of 1875, but after investigation, the Crown carried no action against Dumont or the St. Laurent group.

Thomas McKay, first mayor of Prince Albert was Clarke's brother-in-law.

He was the first elected Member of the Legislative Assembly in Northwest Territories' history.