Lawrence Coleman Kolb (June 16, 1911 – October 20, 2006) was an American psychiatrist who was the New York State Commissioner of Mental Hygiene from 1975 to 1978.

During World War II, he went into the Navy and was stationed aboard hospital ships and then put in charge of a clinic for "battle fatigue" in Portsmouth, New Hampshire.

After the Navy, Kolb worked at the National Institute of Mental Health in Bethesda, Maryland (where a collection of his papers are held) [2] and the Mayo Clinic in Rochester, Minnesota.

In 1954 Kolb was appointed chairman of the Department of Psychiatry at Columbia University Medical Center and director of the New York State Psychiatric Institute.

Many years later he led a significant study on "battle fatigue" in Vietnam veterans, finding that post-traumatic stress disorder could cause physical signs and symptoms.