[2] He is the first recipient of the Francis Bacon Medal for significant contributions to the history of science.

[3] Principe's research has been supported by the National Science Foundation, the National Endowment for the Humanities, the American Philosophical Society, the Chemical Heritage Foundation, and a 2015-2016 Guggenheim Fellowship.

[10] Principe was the first historian of science to bring the reconstruction of alchemical experiments as a historical tool into the mainstream of scholarship, reproducing a number of experiments and reconstructing methods, tools, and settings reported by alchemical texts in his modern laboratory while accounting for impurities in substances used, conditions for the experiments, and other factors.

[11] His book The Scientific Revolution: A Very Short Introduction (Oxford, 2011) describes and contextualizes the important scientific developments that took place from about 1500 to 1700, and explores the worldviews and motivations of the people responsible for those developments; it has been translated into Arabic, Chinese, Japanese, Korean, Spanish, and Swedish.

He is the first recipient of the Francis Bacon Medal by the California Institute of Technology for significant contributions to the history of science in 2004.