Lawrence Sydney Nicasio was born on 5 September 1956,[1] and came from a Garifuna family.

[3] In 1981 he began studying philosophy at Cardinal Glennon College in Shrewsbury, Missouri, which was followed by studies at the theology college on the same grounds, Kenrick Theological Seminary, near St.

[6][4][7] He received episcopal consecration from the Apostolic Nuncio in Belize, Archbishop Léon Kalenga Badikebele, on 13 May 2017.

Co-consecrators were the Archbishop of Nassau, Patrick Christopher Pinder, and Fernand J. Cheri, OFM, Auxiliary Bishop in New Orleans.

Nicasio died from cancer at his residence in Belize City, on 1 January 2024, at the age of 67.