Nyalandu pursued his undergraduate studies at Wartburg College in the United States, where he graduated with a Bachelor of Arts in Business Administration in 1997.

Prior to joining party politics, Nyalandu worked as an international affairs and development advisor for the Equal Opportunity Trust Fund, Tanzania from 1999 to 2000.

In May 2014, Nyalandu convened a conference that brought together international development partners including the UK, US, EU, UAE, EAC, World Bank, UNDP, GEF, ADB, EABD, and other countries to which ivory is sold such as Japan, China, and Vietnam.

[3] As Minister of Natural Resources & Tourism, Nyalandu took major initiatives through global forums to bring new hotel and infrastructure investment to Tanzania.

He succeeded in winning the bid for Tanzania to host, for the first time, the annual Africa Hotel Investment Forum scheduled for 2015.

[6] As Deputy Minister for Industry and Trade, he forbid Chinese people from working as vendors in Dar es Salaam markets.