In December 2010, Le Bonheur Children's Hospital opened the emergency department in its newly renovated 12-story patient care tower.

While it is primarily located in Memphis, the system also owns the Methodist Olive Branch hospital in Mississippi.

[8] Like the other 2 major systems in the region, the parent company filed collections actions against patients who have difficulty paying, with 8,300 lawsuits between 2014 and 2018.

[11][12] Le Bonheur is affiliated with the University of Tennessee Health Science Center and St. Jude Children's Research Hospital.

Le Bonheur Children's Hospital has been ranked among the nation's best by U.S. News & World Report in different specialties.