The relatively large Swiss mansion was built between 1765 and 1771 for Pierre-Alexandre DuPeyrou (1729–1794) by the Bernese architect Erasme Ritter (1726–1805).
His fortune derived from his two slave plantations in Suriname where he was born and where his father was in a high position within the Court of Justice.
It was DuPeyrou who paid the costs for the first publishing of the complete works of Jean-Jacques Rousseau in 1788 in Geneva.
[1] DuPeyrou and his wife, Henriette Dorothée de Pury (1750–1818), had no children.
Today the Hôtel DuPeyrou contains a restaurant and it is also used for ceremonial events by the city.