Jean married Charlotte, daughter of Antoine de Mailly, lord of Auchy and Neuville-le-Roy, and Marie d'Yaucourt.
They had a daughter, also Charlotte, who married firstly Claude des Essars, lord of Sautour, and secondly René, comte de Sansay, hereditary viscount of Poitou.
In 1530, he was one of six knights chosen by the king to defend a pas d'armes at the arrival of Francis's bride, Eleanor of Austria.
Jean lost his generalship of the artillery on 11 April 1547, being replaced by Charles de Cossé, Count of Brissac.
[5] He remained governor of Loches until he resigned the office to Honorat de Savoie, Count of Villars.