Lee County is included in the Tupelo Micropolitan Statistical Area.

[3] As of the 2020 United States Census, there were 83,343 people, 30,378 households, and 21,437 families residing in the county.

25.00% of all households were made up of individuals, and 8.50% had someone living alone who was 65 years of age or older.

Lee County has the ninth highest per capita income in the state of Mississippi.

The last Democratic presidential candidate who carried this county was Jimmy Carter in the election of 1980.