The native of Zealandia, Saskatchewan, was a left-handed pitcher who worked in 68 games pitched, 12 as a starter, in the Major Leagues over three seasons for the Pittsburgh Pirates (1941–42; 1946).

After winning 13 games for the 1940 Seattle Rainiers of the Pacific Coast League, Wilkie was acquired by the Pirates that August.

During his rookie campaign, he pitched the only shutout of his MLB career, blanking the Philadelphia Phillies 5–0 on six hits on June 9, 1941.

[1] Wilkie served in the 36th Infantry Division of the United States Army in the European Theater of Operations during World War II,[2] and was out of professional baseball from 1943 to 1945.

During his time in the Major Leagues, Wilkie allowed 215 hits and 80 bases on balls in 194 innings pitched, with 37 strikeouts, three complete games and three saves.