[1] This legion was possibly founded in Italy during the 48 BCE Julius Caesar, who needed it in his war against Pompey.

[5] They were subsequently present at the siege of Perugia in the winter of 41 BC, where Lucius Antonius, Mark Antony's brother, had taken refuge.

[3] After Augustus became Emperor, in 30 BC it was moved to Juliobriga in Hyspania Tarraconensis to fight the Cantabrian Wars.

[3] Emperor Claudius likely transferred the legion to Mainz in Germania Superior to replace the XIV Gemina.

Some people think that the legion was transferred in 39 AD, when emperor Caligula waged war against the Germanic Chatti.

While stationed in Germania the Fourth shared the fortress with the recently founded XXII Primigenia.

During the revolt the IV Macedonica guarded Mainz against attacks by Germanic Chatti, Usipetes and Mattiaci.

[5] The new Legio IV Macedonica was moved to Burnum, a Roman military camp in Dalmatia.