[5] George was born in Sydney, New South Wales, Australia,[3][4] to actor and producer Vincent D'Onofrio and actress Greta Scacchi,[2][6] and raised by her mother in Hurstpierpoint near Brighton, East Sussex, United Kingdom.

The following year, she attended Crawley College, her mother's alma mater, and in 2010, studied at the Arts Educational Schools, London.

In 2012, she went to the United States to study at the Lee Strasberg Institute in New York City near her father.

In 2014, she starred with her mother in Anton Chekhov's The Seagull for Black Swan Theatre Company in Perth.

[3] In 2019, George began playing the younger version of Ellen Barkin's character, Janine "Smurf" Cody, in the television series Animal Kingdom.