[2] L. jamaicensis was a large lizard species that could grow up to 130 mm in snout-vent length.

Fossil evidence suggests there may have been two distinct variants of this species, as shown by different frontal bone structures: one specimen found in Portland Cave had a wide posterior with well-developed rugosities, while another from Montego Bay Airport Cave was narrow and smooth.

The fossils have been discovered at several locations across the island, including: This species was part of a broader distribution of Leiocephalus lizards throughout the West Indies, with fossil evidence showing that the genus once ranged across all main islands of the Greater Antilles and likely most of the Lesser Antilles as far south as Martinique.

The most recent fossils from Marta Tick Cave were dated to approximately 770 ± 70 years before present.

This timing, along with other Leiocephalus species that became extinct around European settlement, provides insights into relatively recent ecological changes in the Caribbean.