She was chair of the English literature department at McTyeire Institute in Shanghai from 1910 to 1926, and dean of women at Soochow University from 1926 until 1941.

Her eldest brother, Herndon Tuttle, was a friend of Charlie Soong, giving her an early connection to Chinese Methodists.

[4] She was head of the English literature department at McTyeire Institute in Shanghai until 1926, when she became dean of women at Soochow University.

[5] Tuttle spoke about her experiences in China to community and church groups on her furlough visits to North Carolina,[6][7] and in her later years.

[12] Twenty boxes of her papers and artifacts from China are held by the special collections library at UNC-Greensboro.