[8] Starting at just four years old, on her father's initiative, Katina began to attend various sport and music clubs.

In 2007, both girls appeared in the US–Russian drama film You and I, which starred Mischa Barton in the lead role and was based on the 2006 Aleksey Mitrofanov novel t.A.T.u.

In 2010, she hosted a fan event at the Trail in Los Angeles on 29 May[11][12] and gave her first solo performance the next day at the Troubador.

[13] She was the opening act of PrideFest in Milwaukee on 12 June 2010[14] and on the same day, she released a free download of a song from her upcoming album, titled "Lost in this Dance".

[15] She also contributed vocals to the song "Guardian Angel" by Canadian electronic metalcore band Abandon All Ships, which was featured on their 2010 debut album, Geeving.

On 17 June 2011, Katina's single "Never Forget" premiered on the Mexican radio station FMTU 103–7 in Monterrey.

[17] In July, Katina and her band appeared on Rawsession, where they performed original acoustic versions of Owl City's "Deer in the Headlights", Alexandra Stan's "Mr. Saxobeat", and her own "Never Forget".

[19] In September 2011, Katina released the song "Waiting"[20] and featured on the track "Tic-Toc" by Mexican pop band Belanova.

[24] On 24 September 2013, Katina issued the single "Lift Me Up", which peaked at number 31 on the Billboard Dance Club Songs.

In September, she announced via Facebook that her debut studio album, This Is Who I Am, would be released on 18 November 2014, preceded by the single "Who I Am" on 7 October.

[30] Alongside Katina, the panel of judges included Valentina Pyatchenko and Yekaterina Shklyayeva, members of the ethno-pop group Buranovskiye Babushki.

[32][33] Katina released a number of singles in 2020, including "Virus",[34] "Убей меня нежно" ("Killing Me Softly"),[35] "Crybaby",[36] and an English version of "Никогда", titled "Nevermind".

[40] On 27 January 2023, she issued the single "Tакси" ("taxi"), from her upcoming Russian-language EP, Манекен ("mannequin"), which came out on 28 April.

[41] After a maternity hiatus of over a year, Katina released the single "Маяк" on 6 December 2024,[42] and she featured on the track "Новый год" by Russian singer Oksana Pochepa.

[45] She announced in November 2014 that she was three-and-a-half months pregnant with her first child during a concert in Rome[46][47] and gave birth to a son on 22 May 2015.

[49] In June 2021, Katina revealed that she was in a relationship with Russian businessman Dmitry Spiridonov, the CEO of CloudPayments.

The organisers noted that "Lena's participation in Queerfest is a truly historic moment: for the first time such a high-profile Russian artist supports the festival".

bandmate, Julia Volkova, appeared as a contestant on a Ukrainian game show called Lie Detector and made comments considered to be highly homophobic, especially towards gay men.

Xoxo[57]In 2010, Julia Volkova expressed her opinion on Katina's solo career, saying, "[Lena] has the right to [sing t.A.T.u.

While the duo reunited briefly in 2012–2014, with a performance at The Voice of Romania while promoting the re-released edition of 200 km/h in the Wrong Lane, a concert in Kyiv, and a pre-opening performance at the 2014 Winter Olympics in Sochi, on 17 February 2014, Katina posted a video message on her official YouTube channel, stating that she would no longer be working with Volkova.

[60] On 22 May 2014, both singers introduced their appearance in Cornetto Russia's A Sight of Cupid project while at the Cannes Film Festival.

[61] In 2016, Katina and Volkova appeared together at the 25th anniversary celebration of the children's musical group Neposedy, of which both were members before t.A.T.u.

Katina performed her song "All Around the World", and together with Volkova, sang "Нас не догонят" ("Not Gonna Get Us").