It results from an original mix of personal experiments, popular music, classical composition - including electroacoustic materials - and jazz.

He studied piano with Bertha Chadicov and Wilser Rossi, harmony with Nydia Pereyra Lisaso, organ with Manuel Salsamendi, and composition with Coriún Aharonián and Graciela Paraskevaídis.

In 1981 his electroacoustic composition "Llanto" was included in the programming of the annual festival of the International Society of Contemporary Music (SIMC) held in Brussels, Belgium.

In June 2003, his opera Maldoror, based on the book Los cantos de Maldoror by the Count of Lautréamont (the famous French poet Isidore Ducasse born in Uruguay), was premiered (and several performances were performed) at the Teatro Colón in the city of Buenos Aires.

Leo Maslíah also published nearly 40 books, including novels, collections of short stories and plays.

His works Telecomedia and El mouse were awarded the prize of the Ministry of Education and Culture of Uruguay, in the "comedy" category, in 2000 and 2013.