Leonardo da Vinci was originally housed on the 4th Floor of the Koessler Administration Building (KAB) on the D'Youville College Campus and shared space with the Grover Cleveland High School for electives.

The school moved to Madonna Hall building on the D'Youville College campus.

Students who attended DaVinci had the opportunity to take college credit-bearing classes from D'Youville.

In August 2023, the school was temporarily relocated to 167 East Utica Street.

Leonardo da Vinci High School offers varsity sports including: Students who are interested in playing a sport da Vinci does not offer are able to try out at Hutchinson Central Technical High School.