The building, located at 666 East Delavan Avenue in Buffalo, currently serves home to The Math, Science, Technology Preparatory School.

Seneca was the oldest vocational high school in Buffalo, and was constructed three months after the first vocational school in the state of New York was completed.

In the fall of 2006, the school reopened as the Math Science and Tech Prep at Seneca.

During that time, MST Prep students were educated at Black Rock Academy until Seneca was ready to be re-opened.

Previous assignment and reason for departure denoted in parentheses