Leone Pompucci graduated from the Avogadro institute in Rome, followed by studies at the National Santa Cecilia Conservatory.
He conceived and produced covers for the most important Italian and European weekly magazines: Der Spiegel, L'Express, Panorama, L'espresso, L'Europeo and Famiglia Cristiana.
Equipped with that experience he made his first film, Mille bolle blu, for which he received the David di Donatello award for best young director in 1994.
Then, the RAI entrusted him with the realization of twelve episodes of the successful TV series Don Matteo.
This biographical film set around 1908 is based on the story of the Italian marathon runner Dorando Pietri.