[3] Shaun Lindsley of Metal Hammer said "with Scream Bloody Gore having set a new standard in extremity, [...] Leprosy would end up being the final nail in Death’s thrash-tinged coffin.

[7] The lead guitar stylings of Rick Rozz on the album utilize whammy bar divebombs, drawing comparisons to Kerry King of Slayer.

Jonathan Horsley of MusicRadar assessed, "Even this early in his [career], Schuldiner was a provocateur, upending the songwriting rule book, eschewing repetition, operating like the editor of an action movie in cutting together contrasting riffs and ideas with brutal efficiency.

[3] "Pull the Plug" is written from the perspective of a person who is being taken off of life support,[8] and has been called "a death metal contemporary of Metallica’s One".

[But,] if Leprosy is not the heaviest death metal guitar album, it’s possibly the gnarliest, worthy of Ed Repka’s career-best cover art, and essential listening.

"[10] In a poll by the German Rock Hard magazine, Leprosy was voted the number one of the 25 most important death metal albums of all time.