Les Horribles Cernettes was founded in 1990 by Michele de Gennaro, a graphic designer at CERN, whose romantic relationship with a physicist was made difficult by his numerous shifts.

She attracted attention by stepping on stage during the CERN Hardronic Festival,[5] singing "Collider", a melancholy song about the lonely nights endured by the girlfriend of a high energy physicist.

The group was subsequently formed with the help of Silvano de Gennaro, an analyst in the Computer Science department at CERN, who wrote additional songs.

The fame of Les Horribles Cernettes grew and they were invited to international Physics conferences and The World '92 Expo in Seville, as well as celebrations such as Georges Charpak's Nobel Prize party.

[10] On July 15, 2017, and in celebration of their 25th anniversary (of their historic exposure on the World Wide Web), the original members performed for a one-time-only concert in Geneva.