Leslie Clyde Mueller (March 4, 1919 – October 25, 2012) was an American right-handed pitcher in Major League Baseball who played for the Detroit Tigers in 1941 and 1945.

In 1940, Mueller played for the Beaumont Exporters in the Texas League and threw a no-hitter on August 22, 1940 against Dallas.

The following year, Mueller reached the big leagues, pitching four games for the Detroit Tigers.

He enlisted in the Army after the United States entered World War II and missed the next three seasons.

After his baseball career ended, Mueller returned to Belleville, Illinois, where he worked in the family's furniture store until he retired in 1976.