Frank W. Overmire (May 16, 1919 – March 3, 1977) was an American Major League Baseball pitcher who played ten seasons for the Detroit Tigers (1943–1949), St. Louis Browns (1950–1952), and New York Yankees (1951).

In ten seasons, Overmire won 58 games and lost 67 with a 3.96 earned run average.

In 1945, Overmire started 22 games, and won 9, for the American League pennant winning Tigers.

Overmire went on to pitch for the St. Louis Browns from 1950 to 1952 with a short stint with the New York Yankees at the end of the 1951 season.

After his playing career ended, Overmire became a manager in the Tigers' minor league organization.