[2] The middle course of the Mezen, the current area of the district, was where Russian and Komi cultures mixed the most.

[11] In the course of the administrative reform carried out in 1708 by Peter the Great, the area was included into Archangelgorod Governorate.

[12] The district lies almost entirely in the basin of the Mezen River, which crosses the district from southeast to northwest, and of its major tributaries, the Mezenskaya Pizhma, the Sula, the Kyma, the Vashka, the Kimzha, and, in the northern part, the Pyoza.

Some areas in the east of the district are in the basin of the major tributaries of the Pechora, the Tsilma, and the Pizhma.

The northern part of the Timan Ridge lies in the district, creating the hilly landscape.

However, although the district has the best timber resources in the area, poor infrastructure impedes the expansion of this industry.

The Mezen horses are rather small but suitable for difficult work and easily survive cold winters.

During winter, temporary roads (zimniks) are built in snow; in summer, the air transport is the only means for passenger connections to Arkhangelsk and the rest of the world.

[17] The district contains three objects classified as cultural and historical heritage by the Russian Federal law, and additionally thirty-nine objects classified as cultural and historical heritage of local importance.

The objects under federal protection are the St. Nicholas Church (1890), the Klokotov House (1879), and the wooden cross, all in the village of Zaozerye (also known as Kelchemgora).

The Klokotov House was moved in 2004 to the Malye Korely open-air museum close to Arkhangelsk.