Lesina Cathedral (Italian: Cattedrale della Santissima Annunziata) is a Roman Catholic church and former cathedral dedicated to the Annunciation of the Virgin Mary located in Lesina, in the region of Apulia, Italy.
Rebuilt over the centuries, the building was destroyed by an earthquake in 1630.
By the 1650s, another church had been built, dedicated to the Annunciation and consecrated in 1691, which was replaced in its turn in 1828–1837.
The interior has frescoes depicting the Life of Christ by Bocchetti Gaetano.
This article about a Roman Catholic church building in Italy is a stub.