Letcombe Regis is a village and civil parish in the Vale of White Horse.

The village is on Letcombe Brook at the foot of the Berkshire Downs escarpment about 1 mile (1.6 km) southwest of the market town of Wantage.

[1] The parish includes Segsbury Camp, an Iron Age hill fort on the crest of the Downs just over a mile south of the village.

The centre was initially a UK government laboratory, but was sold to the chemical company Dow Elanco in 1985.

[3] Letcombe Regis has a public house, the Greyhound Inn[4] and a village hall.