Her introduction to this world was facilitated by her elder sister Lydia when she joined Itala Film, a prominent production company based in Turin at the time.

Her cinematic debut occurred in 1912 with the film T'ho ancor baciato, or muoio lieta!

[3] From 1913 onward, she established herself as a regular actress at Itala, where she notably portrayed Elena, sharing the screen with her sister Lyda, who assumed the role of Dorina in Cammasio's Addio giovinezza (1913).

[3] In a short span, Letizia Quaranta emerged as one of the most sought-after actresses of her era.

Their collaborations extended from the late 1910s to the early 1920s and included noteworthy works like Maciste innamorato (1919), La trilogia di Maciste (1920) starring Bartolomeo Pagano, and Hedda Gabler (1920) featuring Italia Almirante Manzini.