Letohatchee is an unincorporated community in Lowndes County, Alabama, United States.

This was an area of extensive cotton cultivation into the early decades of the 20th century, and Lowndes County was majority black.

In 1917 William Powell and his brother (recorded as Samuel or Jesse) were both lynched for alleged insolence to a white farmer on the road.

On July 31, 2016, a historical marker was erected by the Equal Justice Initiative to commemorate these extrajudicial executions.

[6] Letohatchee has two industrial plants, four convenience stores and one restaurant/cattle yard and a post office.