George II led a series of unsuccessful raids into his western neighbor, kingdom of Kartli, ruled by a rival branch of the Bagrationi.

Having secured the crown, Levan forced the highlanders of eastern Georgia into submission and established friendly relations with the Shamkhal of Tarki in Dagestan.

In the 1555 Treaty of Amasya, Ottoman and Saffavid empires divided the South Caucasus in their spheres of influence, with Kakheti falling into the Iranian orbit.

Pressured by the presence of an Iranian army near the Kakhetian borders, Levan had to send his son Vakhtang (also known as Jesse) as a political hostage to the Saffavid court where the prince was converted to Islam, named Isa-Khan and appointed a governor of Shaki.

In contrast to other parts of Georgia, the towns and countryside prospered and attracted people from the harassed lands of Kartli as well as Armenian and Persian merchants and craftsmen.

She gave birth to at least two sons: Levan divorced Tinatin in 1529 and married a daughter of Kamal Kara-Musel, Shamkhal of Tarki.