[4] His children are actors Patricia, Alexis, Rosanna, David, and Richmond Arquette.

He is the former father-in-law of actress Courteney Cox, film composer James Newton Howard, and actors Thomas Jane and Nicolas Cage.

His wife, Brenda Olivia "Mardi" (née Nowak), died in 1997 from breast cancer.

She was Jewish and the daughter of a Holocaust refugee from Poland, while Lewis Arquette, raised a Catholic,[7] was a convert to Islam.

[8][9][10][11] Arquette died in Los Angeles, California on February 10, 2001, at the age of 65, due to congestive heart failure.