[1] Clayton was born in London in 1838, the son of John Clayton, a solicitor He was educated at King's College School and Emmanuel College, Cambridge, where he graduated in 1860.
[2] He was ordained deacon in 1861 and priest in 1862, his first post was as a curate at Holy Trinity, Halstead.
While in Leicester he also spent four years as rural dean in the area.
[4] From 1887 he was a residentiary canon at Peterborough Cathedral,[5] and he was proctor in convocation from 1892.
He was appointed suffragan bishop of Leicester in January 1903;[4] he resigned the see (retaining his cathedral residential canonry) and became an assistant bishop of Peterborough (in retirement) in December 1912[6] serving as such until his death in 1917.