Lewis Creek is a tributary of the Susquehanna River in Luzerne County, Pennsylvania, in the United States.

The creek is not designated as impaired and has typical water chemistry for a stream of its geology and land use.

[1] Lewis Creek joins the Susquehanna River 202.94 miles (326.60 km) upriver of its mouth.

[4] The rocks in the watershed of Lewis Creek mainly consist of Devonian sandstones, shales, and siltstones of the Catskill Formation.

[2] The mouth of the creek is in the United States Geological Survey quadrangle of Ransom.

However, rural residential areas and a small amount of agricultural land occurs along the creek's corridor.

[4] A bridge carrying that route crosses Lewis Creek in Exeter Township.

[8] As of 2005, the population density of the watershed of Lewis Creek is 77 people per square kilometer.

[4] Lewis Creek was entered into the Geographic Names Information System on August 2, 1979.

[6] In 1845, a plaster and clover mill was being operated on Lewis Creek by Lloyd Jones.

[4] The creek and several dozen other streams in Pennsylvania were evaluated for High-Quality Coldwater Fishery status in 2012.

[10] The mouth of Lewis Creek is near the Apple Tree Access Ramp of the Pennsylvania Fish and Boat Commission.

Other fish species inhabiting it include central stoneroller, spottail shiners, swallowtail shiners, bluntnose minnows, eastern blacknose dace, longnose dace, white suckers, tessellated darters, banded darters, and sculpins.