Lewis Run is a borough in McKean County, Pennsylvania, United States.

[3] As of the census[5] of 2000, there were 577 people, 259 households, and 178 families residing in the borough.

There were 287 housing units at an average density of 148.1 per square mile (57.2/km2).

28.2% of all households were made up of individuals, and 14.3% had someone living alone who was 65 years of age or older.

[7] According to the United States Census Bureau, the borough has a total area of 1.9 square miles (4.9 km2), all land.