Lewisburg is an unincorporated community located in DeSoto County, Mississippi, United States.

Lewisburg is approximately 5 miles (8.0 km) south of Olive Branch and approximately 12 miles (19 km) north of Independence along Mississippi Highway 305.

A post office began operation under the name Lewisburg in 1872.

[2] Lewisburg is served by the DeSoto County School District Lewisburg Primary School serves students from Kindergarten to 1st grade.

Lewisburg Elementary School serves students grades 2-3.