It is endemic to western North America in north-central Washington and adjacent British Columbia.

It commonly grows on well-drained slopes often on rocky slopes or in rock crevices from low elevation ponderosa pine sites up to the drier part of the Grand Fir zone of the North Cascades.

[5] The Latin specific epithet tweedyi honours Frank Tweedy, the 19th century American topographer.

The blades of the leaves are sometimes shallowly notched at the apex and are up to 2 inches (5 cm) wide and are ovate.

The petioles appear flattened and the edges are turned upward forming a shallow groove at the base.

Each flower has two sepals and eight to twelve broad petals, a cup-shaped blossom, up to 3 inches (7.6 cm) across.

Lewisiopsis is endemic to the Wenatchee Mountains and Methow Valley of Washington State, and in Manning Park of British Columbia.

[7] Populations may be found near Mount Stuart, Tumwater Canyon, Chumstick Creek, as well as at the top of high ridges.

The nursery trade has taken some interest in cultivating Lewisiopsis because it is perennial, has showy blooms and it is drought tolerant.